Barry attempts to foil the kidnapping of Sofia Tomarquin, daughter of DEA agent Felix Tomarquin, who is scheduled to testify against drug lord Reuben Calderon. However, Calderon's enforcer, Marcos Trachmann, utilizes advanced microscopic devices to control Barry's nervous system and force him to help them kidnap Sofia.

Barry shelters street orphans Terry and Cory Cohan, who have stolen the backpack of a recently murdered journalist, Philip Sullivan, containing Sullivan's research on a highly addictive synthetic drug known as "Blue Paradise", developed by notorious drug designer Beauregarde Lesko.