J.D.'S efforts to make a good impression on a first date reach desperate levels when he and Kylie get caught in a hospital quarantine. A series of unfortunate events bring J.D. And Kylie to Sacred Heart on their first date, where J.D. accidentally initiates a SARS quarantine and is forced to resort to desperate measures to make a good impression. While the hospital is in lockdown, the rest of the staff recounts various first date stories leading to the revelation that Dr. Cox and Carla dated in the past.

Turk and Carla ask J.D. to move out to give them some space to rekindle the romance in their relationship. Suddenly homeless, J.D. tries to use the situation to his advantage by asking his girlfriend Kylie if he can stay at her place. Meanwhile, Dr. Cox gets a visit from his high school friend Ron. Dr. Cox and Ron's relationship has always been highly competitive, and just when Dr. Cox thinks he has the upper hand, the discovery that Ron's son may be autistic sends them into unfamiliar territory.