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Monk and Natalie go to Berkeley for Monk's 25th college reunion, but are sidetracked when Stottlemeyer shows up asking for their help on the recent homicide of a retired clinic nurse.
With work scarce from the police department, Natalie manipulates Monk into opening his own agency, but his first case may be deadly.
Dr. Kroger questions his abilities after a patient becomes the prime suspect in a murder. He decides to retire but a distressed Monk is convinced someone else is responsible.