An entire family suffering from carbon monoxide poisoning is brought to the ER. Claustrophobic Neela must spend a couple of hours in a hyperbaric chamber with the family's newborn baby. Carter misses Kem, who's been gone for a month now, so Jerry arranges a webcam chat for them. Luka and Sam have been keeping their relationship a secret from Alex, although he finds out and isn't too thrilled about it. After Sam suggests they take their relationship slower, Luka isn't too thrilled either. Dr. Lawson asks Elizabeth out. Sandy's mom brings Weaver's son Henry in. Chen returns from China: her dad needs 24 hour nursing care and she's having trouble getting adjusted to that idea. Susan and Chuck visit her dad and tell him about the pregnancy.

Carter sticks up for Neela when the other attendings doubt her capabilities and future in the ER. Ironically, Neela caves under pressure and accidentally gives a patient the wrong medication, though no one finds out, as Gallant covers for her and takes the blame. Sam and Luka try to plan Alex's birthday party. Frank visits on his way to therapy. Chen's home nurse quits after Chen's dad behaves abusively. Chuck confronts a man who is a bit too interested in Susan's pregnancy. A flasher tangles twice with a tough group of Catholic school girls.