A 16-year-old is brought in with renal failure after a kidney transplant, and Carter concludes that a new drug she was taking for her condition is the culprit. He creates a media uproar and a public relations nightmare for the hospital when he openly questions the safety of the drug, which happens to have been recommended by the girl's neurologist, George Henry, a former student of Carter's. Meanwhile, Neela's crush on Luka is resolved, and med student Jake reveals an increasing interest in Abby.

Weaver is spending the day working in the ER when she meets her birth mother, who has disguised herself as a patient in order to meet Kerry. An evangelical Christian in town with her choir, she is deeply taken aback when she discovers that Kerry is gay. In the meantime, Jake and Abby have trouble hiding their relationship at work, Pratt warily hands a patient over to Jane, and Carter confronts a pair of Demerol junkies.