New nurse manager Eve Peyton causes a stir in the ER. Luka and Kerry treat a severely burned man. Abby helps a woman who might have breast cancer make a difficult decision, then makes a discovery about Dubenko. Sam and Luka find it difficult to work together.

There's a new attending in the house, Dr. Victor Clemente, and he has not made a great first impression. Clemente puts the residents through their paces, alienating Pratt and infuriating the R2s. Luka spends the day with recently awakened coma patient Blaire. As Luka struggles with whether or not to tell her about her accident, Blaire tries to make sense of her flashes of memories, resulting in a tragic event. In the ER, Luka and Clemente clash over her treatment, and Luka finally tells her what happened, possibly too late. Abby visits her cancer patient, leading her to get a baseline mammogram. Dr. Dubenko's surgery goes well, and Ray meets a new girl at a rock concert.