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Kovac is in Chicago looking for hospice-care work. Neela's aorta surgery has caused an infection in her patient. Abby treats a teen who has been beaten up. Brenner continues to cause problems for the ER staff.
Neela, worn out after her final ortho shift, has to stay on duty when a scheduling mistake has her surgical trauma shift starting immediately. Sarah's grandparents are in town, and Hank is taken to the ER after collapsing during an outing. Gates tries to convey to Sam that his feelings for her are serious. Pratt and Sam treat a father who shows signs of having been physically abused by his son.
There's been a jewelry robbery in town, and Neela finds out that one of her patients might have had something to do with it. Pratt makes an effort to save his relationship with Bettina, and Abby worries about her marriage, sensing that Luka may have given up on it.