Benton's attempts to get away to Carla and Reese on Christmas Eve are continually thwarted by Romano, culminating in Benton forcing the drunken Romano away from a patient. Carter believes he's found a Christmas miracle when a teenage girl with a rare blood type needs an organ donation at the same time a brain-dead patient with the same blood type is in the hospital. After witnessing Dr. Lee rifling through Greene's locker, Jerry becomes convinced that she's stalking Mark.

Doug jeopardizes future federal grants for the entire ER when he breaks a double blind study by giving a sample drug to an ailing patient. Doyle lodges a sexual harassment complaint against Romano, hoping Dr. Corday will lend support. Lucy begins her surgery rotation under Benton's tutelage. The two of them treat a man claiming to be 140-years-old. Mark declines to proceed in the NASA program. Carol questions Lynette's intentions when she hosts a women's health clinic for African American women only. Mark goes to bat for Pickman when she inadvertently leaves a severely injured man at an accident scene.