Third year med student (and part-time OB nurse) Abby Lockhart begins her ER rotation. A flu bug sweeps through the ER. Carter tries to help a kid with muscular dystrophy while Cleo treats a kid who's been injecting hormones into himself. Corday discovers that her mother will be coming to town and then decides to pay her a visit. Lucy treats a dying homeless man. Benton and Romano clash over the treatment of a surgical case. Luka and Carol treat a young boy whose mother is injecting him with saline to get surgical procedures done.

Carter and Lucy are found almost bleeding to death by Weaver. The two are worked on in trauma and then are operated on up in Surgery. Lucy's injuries appear serious when her chest needs to be cracked open. Because of Anspaugh's quick thinking, Carter survives, however, Corday and Romano are unable to save Lucy, which throws the ER into devastation. Cleo is forced to crack open a man's chest to save his live when no surgeon is available, much to Benton's dismay. Lucy and Carter's attacker is found after he is hit by a car, and he is admitted to Psych with schizophrenia.