Corday discovers that her mother and David Greene spent the night together. Greene later discovers that his father has lung cancer. Lucy's mother visits the ER to empty her daughter's locker and pay a visit to Carter, who is regaining strength and recovering. Abby goes behind Weaver's back with a patient on a gut instinct. Luka witnesses a hit-and-run accident and rushes the victim to the ER in a plumber's truck. Carol must tell a promiscuous, sexually active 14-year-old that she has cervical cancer.

Mark and Elizabeth squabble after he disagrees with her treatment of his father. Carter gets in trouble when a patient that he had discharged for insurance reasons comes back into the hospital near death. Weaver is suspended after disobeying a direct order from Romano, regarding the care of a mentally challenged girl. Kovac and Corday are faced with a blitz of possible kidney receivers, but Luka has a problem with the one who gets it. Cleo and Benton endure Romano's ire for scribing a messy prescription that nearly kills a man; they later have sex on the stairs at her place. Chen faces some personal obstacles when treating a man who refuses to tell his daughter about his genetic condition.