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On New Year's Eve, Dr. Greene undergoes a dangerous, experimental medical procedure in New York with Corday by his side; a guilt ridden father injured in an auto accident fears for his son despite his own critical condition.
During labor Chen has second thoughts about giving her baby up for adoption, a decision complicated by the adoptive parents' presence at the hospital. With an enormous lack of sleep, Carter is called back to County to act as Chen's coach, and is later tempted to use Vicodin to take the edge off. Finch and Benton encounter trouble trying to keep Kynesha hidden from a gang. Benton comforts a little girl who is feeling used by her parents. Legaspi plants a kiss on Weaver. Greene and Corday spend the day in New York seeking help for his brain tumor. Weaver has the hiccups throughout the entire episode, trying several suggestions to stop them.
Kovac treats a bishop who took a fall and questions Luka's faith. Abby pressures Carter to tell Weaver about the Vicodin he nearly took. Abby later tells him that she cannot be his sponsor anymore. After Kynesha is placed with a foster family, Benton and Finch discover their home trashed by her. Corday's malpractice suit is settled; Mr. Patterson later visits her at the hospital, causing Elizabeth to panic with another patient. Weaver and Legaspi are divided over personal and professional issues. Carter treats a woman smuggling drugs by swallowing a condom full of cocaine.