Abby's mother decides to stay in Chicago, causing Abby even more trouble. When Weaver accepts Dr. Legaspi's dinner invitation, Weaver learns that she has misunderstood Legaspi's intentions. Carter tries to find a drug addict who has left the hospital against medical advice. Chen's mother visits the ER and invites her to dinner, even though she is surprised by Chen's pregnancy, and speechless when Chen tells her that the father is black. Greene discovers that he has a brain tumor. Corday is sued for malpractice by Mr. Patterson, the patient whose surgery she rushed so she could start her vacation, and later discovers that she's pregnant. Carter saves Abby after an explosion in exam room three.

During labor Chen has second thoughts about giving her baby up for adoption, a decision complicated by the adoptive parents' presence at the hospital. With an enormous lack of sleep, Carter is called back to County to act as Chen's coach, and is later tempted to use Vicodin to take the edge off. Finch and Benton encounter trouble trying to keep Kynesha hidden from a gang. Benton comforts a little girl who is feeling used by her parents. Legaspi plants a kiss on Weaver. Greene and Corday spend the day in New York seeking help for his brain tumor. Weaver has the hiccups throughout the entire episode, trying several suggestions to stop them.