Abby has a horrible birthday, beginning with meeting her new squabbling neighbors. She treats a young woman hoping to get pregnant by taking fertility drugs, and discovers that Luka is going to Bosnia for two months as part of the Doctors Without Borders program. Her ex-husband tells her that he's getting remarried just before she sees Carter and Susan sharing a private moment. She takes care of a young boy abandoned in the ER after the death of his mother. Paul Sobricki is admitted with a head lac, and Abby unsuccessfully tries to keep Carter from seeing him. Abby's day ends with her sharing a beer with her neighbor. Carter has problems of his own: his mother is back in town, just getting in the way and refusing to admit to her mistakes. He also meets with Chen, who reveals that she has the evidence to take Weaver down in the Marfan's case. Weaver and Lopez are an item until Sandy discovers that Weaver has not come out at work. Mark finds cigarettes and condoms in Rachel's room.

Eleanor Carter tends to a young leukemia patient, trying to make up for Bobby's death many years ago. Mark treats the victims of a letter bomb, and later treats his own daughter when Ella is rushed in after swallowing some of Rachel's Ecstasy. Abby treats a young girl who has been chauffering her drunken mother around. Abby also hides Joyce in her apartment while Brian searches for her and causes a ruckus. An allergic Gallant treats a blind man with a dog. Chen returns to the day shift, working with Weaver for the first time. Romano gives some of Weaver's duties to Lewis, making Kerry mad, until she meets a new friend on her way home.