Eleanor Carter tends to a young leukemia patient, trying to make up for Bobby's death many years ago. Mark treats the victims of a letter bomb, and later treats his own daughter when Ella is rushed in after swallowing some of Rachel's Ecstasy. Abby treats a young girl who has been chauffering her drunken mother around. Abby also hides Joyce in her apartment while Brian searches for her and causes a ruckus. An allergic Gallant treats a blind man with a dog. Chen returns to the day shift, working with Weaver for the first time. Romano gives some of Weaver's duties to Lewis, making Kerry mad, until she meets a new friend on her way home.

Mark learns that his tumor is back and inoperable, giving him 4-5 months to live. Corday is living in a hotel, and confesses to Benton that she thinks she's left Mark. Susan cares for Mark after his first radiation treatment. Abby learns that the case against Brian has been dropped because somebody beat him up. Seeing Brian enter her building, she seeks comfort at Luka's, where he's engaged in a game of Pictionary with his friends. Jerry and Frank clash, leading to a fistfight. Chen has a stalker.