Alderman Bright returns to blackmail Weaver into treating his gay lover for syphilis (off the record, of course). Unfortunately, the man dies from an allergic reaction to penicillin and Kerry is forced to cover up her mistake. Things between Abby and Carter have cooled down following Carter's aborted marriage proposal, but they soon heat up again. Luka has a very unconventional therapy session. Romano's condition forces Anspaugh to replace him as chief of staff...with Weaver.

Abby treats a psychotic patient who has overdosed on his medication. Eric, Abby's brother, finally calls. Dr. Gordana Horvat, who attended medical school with Kovac, brings a boy from Croatia who needs heart surgery. Gallant and Pratt receive their match letters. Carter receives bad news about his grandmother. Romano discusses grave options about his arm with Corday.