Eric McCormack will show clips of past and present episodes that highlight the series' most iconic and memorable moments. The retrospective will also feature emotionally-charged reactions from "Will & Grace" superfans and celebrities who will share stories about what the show has meant to them. The special will cover the litany of guest stars who have appeared as well as the groundbreaking and TV history-making moments the show has created over the years, including the first male-to-male kiss on network television. Elton John and Norman Lear will also make special appearances.

With the apartment packed up, Will is determined to not reminisce about his life in the city or his ex, McCoy. Grace, on the verge of giving birth, keeps having false alarms of going into labor. At the behest of Stan, Karen goes to the top of the Statue of Liberty to get closure with her ex-husband. Jack's dream of taking a bow on a Broadway stage becomes a very real possibility.

Karen pulls out all the stops in Blattsville to make the celebration for her baseball team's championship big enough to humiliate Stanley and Danley Walker. While there to support Karen, Will and Grace are shown an open house by a local realtor, leading to a hard conversation about their future living arrangement. Jack learns he's a local celebrity from a Blattsvillian, and has to decide if he wants to stay in the city to pursue his dreams or become a big fish in a small pond.

Will claims living with Grace is like Ricky living with Lucy. When Karen and Jack hear this, they each claim that they are the Lucy of the group. Grace, Karen, and Jack each imagine themselves as Lucy, with Will as the Ricky to all of them. Lucie Arnaz and Leslie Jordan guest star. 

When Will's surrogate, Jenny, tells Will their relationship needs boundaries, Will ropes newly-out Dr. DiLorenzo into going on a fake date so he can spy on Jenny. Unsure if having a boy or girl is more difficult, Grace struggles with popping her gender reveal balloon. During her baseball team's championship game, Karen is torn between celebrating with Friday, and helping Jack build his confidence for a Broadway audition. 

Jack helps Karen sneak into the manse to retrieve her coveted ring, but they're shocked to find it on the hand of Stan's new girlfriend, Val. While hosting Will's surrogate, Jenny, for the weekend, Will and Grace become the old folks they swore they'd never become. 

Will and Grace become convinced Karen is in danger when her new boyfriend, Phil, takes her to a cabin in the woods. With the help of Karen's assistant, Friday, Will and Grace race to save her. Jack makes up a story to a snobby reporter in order to keep his new bar relevant after its previous owner, Miss Coco Peru, steps down. 

Karen introduces Will and Grace to the new love of her life, Phil. But Will and Grace become increasingly suspicious that Phil has sinister intentions for their friend. When Miss Coco Peru tells Jack that he's closing down his bar for good, Estefan encourages Jack to become its new owner.

Despite her history of transgressions, Grace and her neighbor, James, decide to give their relationship one more shot. But when James invites Grace to his job at the aquarium, she endangers his job and a species. In order to help Will deal with his anxiety about becoming a father, Jack takes him to an unexpected place to blow off steam - church. Karen finds herself in a confessional booth, and a visit from Smitty makes her reconsider their entire relationship.

Worried about Grace being a single mother, Marilyn goes behind Grace's back to fix her up with a beagle-breeding couple interested in adopting Grace's baby. Will gets enlisted by Karen to deal with a P.R. nightmare created by a homophobic player on her baseball team. Jack and his husband, Estefan, go to extreme lengths to get rid of a mouse.

Will and Grace decide to intervene when they discover Grace's niece is dating a bisexual man. Jack gets permission from his husband, Estefan, to sleep with his celebrity hall pass, guest star Ryan Phillippe. Karen struggles to adapt when her assistant, Friday, books them on an economy flight. 

When Larry warns Will and Grace about the difficult entry process into the elite school they both want their kids to go to, they set out to prove that their child would be the better candidate. While helping Jenny with her ASMR livestream, Jack unwittingly creates problems between Karen and her "booty buddy," Luke.

Grace and her neighbor, James give their romance another shot - even after she slept with his son and his father. But an embarrassing incident puts Grace's relationship, and her dignity, in jeopardy. Will decides it's time for Jack to grow up, and cuts him off financially. But unlikely wisdom from Jack's husband, Estefan, makes Will reconsider.

Committed to becoming a father on his own, Will meets a potential surrogate with stellar reviews, but her lifestyle choices give Will doubts. In order to gain entry to AnnieCon, Grace pretends to be a formerly famous Annie, while Jack tags along in hopes of completing his celebrity hair E.G.O.T. Karen has a romantic encounter with a disabled veteran.

In the aftermath of Will and McCoy breaking up, Grace and Jack hire the Grief Panda to help Will process his pain. With Karen completely occupied with her new baseball team, Grace believes that she has to fire Karen in order to set her free.

Will and Grace get competitive over whose process of having a baby is more difficult. Jack helps Karen prove to Danley Walker that she'll be a competent owner of her new baseball team. But Karen realizes that an old acquaintance, Amy, may be the help she really needs.

Will discovers a way to finally get back at Jack for years of relentlessly mocking his hairline. Grace is determined to prove to Mrs. Timmer she's strong enough to handle the challenges of being a single mother. Karen gets an invite to Stan's old poker game, and squares off against Stanley's brother, Danley Walker.

When Grace admits she's not sure who the father of her baby is, Karen orchestrates a Mamma Mia situation with the potential baby daddies. Will worries what will happen if he has a straight son, and enlists Jack to help him prepare.

Grace returns from her European travels a new woman, but her elation is short-lived when she receives life-changing news; Karen teaches Will how to be better at phone sex; Jack has a yard sale to discreetly get rid of Estefan's annoying cuckoo clock.