Former Wisteria Lane resident Katherine Mayfair moves back onto the cul-de-sac with her new husband, Adam, a gynecologist who treats Susan, and her daughter, Dylan, who can't remember her onetime best friend Julie. Meanwhile, news about Edie spreads, and Lynette's chemotherapy is wearing her down. As is the fact that she's keeping her cancer a secret. Bree's secret---her fake pregnancy---is also becoming a problem.

Bree gossips about what she overheard in the Mayfair house and reluctantly recommends a gynecologist to Susan; Stella makes brownies to help Lynette through chemotherapy; Edie buys an engagement ring for herself; and while Susan throws a charades party for the neighborhood, Julie and Dylan break into the locked room in the Mayfair house.