Angie decides to leave Wisteria Lane with her family; Bree's affair with Karl becomes harder to hide, causing Susan to clash with Bree; Lynette's pregnancy puts her at odds with Gaby; and Mike and Katherine's argument turns hurtful.

In the wake of the plane crash, the housewives play "What If...," reflecting on their life choices, and on how other choices might have led to different lives. For Susan it's a life with Karl, and for Bree it's one without Orson; and Lynette thinks about a future with her unborn twins. Meanwhile, Carlos imagines Gaby as an overprotective mom; and Angie ponders what could happen if her secrets were revealed.