Sloane is distressed to learn that Prophet Five's cure for Nadia is just as likely to kill her. Meanwhile, the search for Anna Espinosa continues, Rambaldi's prophetic Page 47 resurfaces, and Sydney offers Renee a job at APO.

Sydney must stay undercover and partner with Sark to track down Rambaldi's final clue before Prophet Five finds it. Meanwhile, Vaughn sees daughter Isabelle for the first time, and Rachel discovers Tom's secret.