When Joe suddenly falls violently ill, the group becomes alarmed. Meanwhile Erika discovers an antidote, but refuses to give it to Joe unless he comes clean about his secret. Elsewhere, reporter Renbe and Kat attend Tori's funeral in Rome and discover that her father, the U.S. ambassador to Italy, is also investigating her disappearance.

When Joe wakes up strapped to a table, he is told he must be "reeducated" in order to return to the program, or he will die. He then endures a dizzying array of dreams, hallucinations and flashbacks designed to steer him back to the program and away from Janet. Back in town, both Blackham and McNair are forced to come to terms with their troubled pasts. Elsewhere, continuing their journey in South America, Kat and Renbe try to track down the only person who has ever escaped "the program."