Brooke, Peyton, Haley and Anna have a slumber party at Haley's apartment where secrets and lies are revealed. Meanwhile, when Lucas and Nathan go on a road trip to a Bobcats game, Nathan reveals he is being tested for the genetic defect that caused Dan's heart attack and suggests Lucas do the same. After an awkward encounter with Keith and Jules, Karen and Andy share an intimate night together.

Concerned about his brother's health, Nathan tells Karen Lucas did not take the heart test. Meanwhile, Keith accepts Dan's offer to continue working at the dealership as vice president. Peyton must confront rumors at school that she is a lesbian, which affects her friendship with Anna, while the gap between Nathan and Haley continues to grow.