As news of Peyton's condition spreads, Mouth and Millicent struggle to remain a couple and Brooke tries to suss out Julian's intentions. Peyton and Lucas babysit Jamie and his friend, while Haley and Nathan spend a night out together.

Lucas wrestles with casting for his movie while Peyton tries to prepare for their wedding. Dan advises Jamie on a school crush. Brooke meets the actress who will play her, Nathan gets exciting news, and Haley has to make a tough decision at school. Lee Norris and Antwon Tanner also star.