Kris reluctantly allows Kim to take over the annual Christmas Eve Party, but the holiday is in jeopardy when Kris learns Kim has invited an unwelcome guest, Caitlyn Jenner. Khloe must come to the rescue when North's beloved hamster unexpectedly dies and Kim can't deal. Kris is determined to understand the unconventional relationship between Kourtney, Scott, and his girlfriend Sofia after the three are seen vacationing together in Mexico.

Khloe deals with some debilitating health issues, but her world is turned upside down when rumors surface that Tristan Thompson cheated with Kylie's best friend Jordyn Woods; Kanye brings his family and friends together to celebrate the healing power of music.