The CSIs investigate the death of a young model, whose body was found near a juvenile detention camp for girls. Across town, Delko and Speedle probe the bizarre death of a man who was apparently burned from the inside. Meanwhile, unable to handle the job anymore and feeling that it reminds her of her dead husband's work, Lieutenant Donner resigns from the team for the good, leaving Horatio a note.

The team investigate the manufacture of lethal drugs at mobile labs, and an elderly woman is murdered at a senior home.