The CSIs must investigate the dark side of Miami's nightclub scene when a teenage tourist goes missing. Sara Jennings was on her way to the Bahamas via Miami for a class trip when a wild night of partying, drinking and sex got out of control. Now, the CSIs must discover who she was with and what happened that night in order to find her. Meanwhile, Horatio's past in New York City resurfaces when an old unsolved case lands on his desk.

Three suburban housewives on a girls' weekend in Miami are the prime suspects when the hotel's handsome pool boy is found murdered. When Horatio is tipped off that his team is facing a surprise efficiency review, he must trust Calleigh, Eric, and Ryan to work together to find the killer. However, when they independently follow the evidence, each discovers that their analysis points to a different killer.