The Miami-Dade district attorney loses a highly publicized murder trial in which a husband is accused of killing his young bride and then dumping her body in a lake. However, the woman's body is recovered after the trial concludes, and the 'double jeopardy' clause precludes the husband from being tried again. Now, as the CSIs fear that justice may not be served, new evidence suggests that the husband may have actually practiced on another victim first, and Horatio believes that CSIs may be able to get the husband retried under different grounds.

The CSI team must try to find out who is trying to kill a young couple (introduced in episode 86) who are released from prison. The couple, who become a Bonny and Clyde type "media darlings" soon discover that not everyone regards them as such. Calleigh must work with an ex-friend to help solve the case.