A drug lord is gunned in his Coconut Grove mansion and a suspect arrested at the scene claims he sells marijuana to Delko. Stetler, from Internal Affairs, investigates and the case quickly gets personal when Horatio gets involved. As for the shooting, the CSIs learn that two gunmen may have been involved. Also, Calleigh makes a major decision concerning her job.

The CSIs investigate the brutal murder of a man who was learning how to pick up women at a hot nightclub. Meanwhile, Horatio tries to help out Marisol, Delko's sister, who was arrested on drug charges.