A cruise ship that is docked in Miami is the scene of a double murder. The team investigates the long list of potential suspects and soon the list is dramatically shortened when the CSI's find a large amount of money is missing from the victim's stateroom. Meanwhile Horatio and Marisol's relationship evolves further.

The Mala Noche gang trial is stopped when the defendant escapes with the help of a fake witness and a gunman in the audience. Delko finds that a beautiful but disturbed ex-lover is stalking any woman who he is now close too, including his sister. When a hit is ordered by the Mala Noche gang on Horatio, Marisol however is the one who is critically wounded by a sniper's bullet and later succumbs to her wound and dies. When the gunman is found, Caine and Delko both go vigilante in their desire to see justice done.