When a believer in Santeria, a mix of Catholicism and African voodoo, is found murdered in front of her shrine of animal sacrifices, bizarre incidents start happening around the CSI lab and people speculate that the lab is cursed. However, the case takes an unexpected turn when the CSIs discover that the victim may have been murdered over a tangled plot involving stolen gold.

A murder and kidnapping becomes personal when DNA from a crime scene reveals that Natalia's sister Anya (Natalie Morales) is one of the kidnapped women they are looking for. The team finds a safe full of photos of missing women and they must find the photographer who was using his camera to lure the unsuspecting women. This episode was based on the photographer William Richard Bradford who photographed Eva LaRue's sister.