The CSI team loses Jesse Cardoza when a psychotic genius runs wild in Miami. In the cliffhanger episode from last season, the killer has released a gas into the lab's ventilation system and incapacitated the team. The CSI must find out who the killer is and beat the clock before it's too late.

A blind man is the only witness to the abduction of a young girl and leads the team to a familiar foe, Joe LeBrock. A jailbreak occurs and LeBrock reveals that they are targeting Caine.