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When Wade is infected with a deadly virus on an Earth wracked by an epidemic, Rembrandt and Arturo race to find a cure and free Quinn from a Gestapo-like health agency.
A physics accident sends physics student Quinn Mallory and his companions on an interdimensional roller-coaster ride that lands them in a post-apocalyptic San Francisco. After a narrow escape from death, the Sliders find themselves in a Soviet-ruled U.S., where their only hope of escape is to free an imprisoned revolutionary.
The salvation of a world facing certain destruction rests in the hands of Arturo and a young scientist. Meanwhile, Quinn and Wade begin to face their feelings for each other.