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Cole and Dr. Railly battle the Army of the 12 Monkeys after they both discover the Night Room, an off-site, black ops lab that houses the virus that will one day destroy the world.
A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threaten the mission to save the past.
Cole risks his future to save Dr. Railly after the tragic events of the Night Room create an alternate reality in 2043.
Follows the journey of a time traveler from the post-apocalyptic future who appears in present day on a mission to locate and eradicate the source of a deadly plague that will eventually decimate the human race.