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Jennifer Goines takes her power into her own hands in the year 2016 when she forms the Hyenas, a band of crazy compatriots, to take on the 12 Monkeys. With the help of Cole, an elaborate plot is uncovered to reacquire the virus.
Cassie is sent to 2020 by Jones with one mission: Kill the younger Jones and prevent time travel from ever happening.
Cole has his loyalty tested when Ramse and Railly go rogue, embarking on an unsanctioned mission that sends them to 1961 East Berlin. Once there, they have murder on their minds as they search for an unscrupulous German doctor who knows the location of The Witness.
Cole and Cassie must travel to different time periods to stop The Army of the 12 Monkeys, who seek to unravel time itself. Plus: The identity of the leader of the Army, the Witness, is revealed.