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Donatello experiments with mutagen in an attempt to find a cure for April's mutated father. But one of his experiments goes wrong and he is unleashed in the city.
The Turtles face an army of robot foot soldiers; Karai captures Leonardo and forces him to do battle with ninjas that can adapt to his every move.
Michelangelo plays with some mutagen, contracting a dangerous infection that mutates out of control.