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Donnie finishes a new batch of retro-mutagen in hopes of saving Karai; the Turtles are hunted by Shredder's new henchmen, Bebop and Rocksteady.
As the Turtles search for Karai, they are forced to deal with a city filled with Kraangdroids as well as Zeck and Steranko.
While the Mighty Mutanimals lay siege to TCRI, the Turtles must brave the bizarre world of Dimension X to save the enslaved people of New York.