When a serial killer goes on the rampage, Luther must put his personal life aside and delve inside the murderer's mind to discover what is driving him to kill so many girls, and why. Meanwhile, serial killer Henry Madsen wakes up from his coma, and Alice takes matters into her own hands when Luther cuts off contact with her.

Framed for murder, Luther turns to Alice for help as he sets outs to prove his innocence, and exact revenge on the real killer. But while the two plot, DCI Reed is quietly shoring up evidence against Luther, as the rest of the team are forced to hunt him down.