The Black Panther seeks the Avengers' aid in freeing his African nation of Wakanda from usurper king Man-Ape, and stopping Hydra agents Ulysses Klaw and the Grim Reaper from stealing Wakanda's supply of vibranium.

It's up to Hawkeye, the Hulk, and Thor to save the day when the Leader's gamma radiation ray mutates the rest of the Avengers and threatens to do the same to every human on earth.