Stranded in the Negative Zone, the Avengers must join forces with their enemies - including former members of the Masters of Evil - to fight off an army of strange insectoid creatures that are laying siege to 42.

A mysterious explosion seemingly kills Hank in his college laboratory, but as the Avengers and their friends mourn the loss of their fallen comrade-in-arms, a fearless new vigilante - endowed with the same powers and technology as Ant-Man/Giant-Man and Wasp and calling himself "Yellowjacket" - begins taking out the members of the Serpent Society.