Major Monogram and Dr. Doofenshmirtz host this special episode counting down the top 10 most popular music videos from the show's first season as voted by the fans and viewers, but not without the evil doctor attempting to pull off another scheme to gain power. Fortunately, Perry the Platypus is there to save the day.

Isabella and the Fireside Girls set out to find the rare maraca nut tree so they can get its much needed sap for Phineas and Ferb's bubble invention. Their quest leads them to an old abandoned amusement park. Meanwhile, Pinky the Chihuahua must stop his archenemy, Professor Poofenplotz, from acquiring her favorite brand of hair spray, which she needs to look beautiful enough in order to plan taking over the world. The last of the discontinued product is located at the same amusement park.