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Lorenzo aims to strengthen ties with the Pazzis and proposes a treaty with Venice. Clarice appeals to Lucrezia and learns the way to Lorenzo's heart.
The death of the pope brings strategic challenges as Lorenzo negotiates with the Duke of Milan and welcomes his new bride, Clarice, to Florence.
In opposition to the pope, Lorenzo moves quickly to acquire the strategic city of Imola. A forbidden love flowers between Giuliano and Simonetta.