The Goats are about to face Overland U, their most storied rivals and not to mention, their first televised game of the season. The catch is... they're gonna have to do so without their starting quarterback, Travis James, suspended by the dean for soliciting a prostitute. Coach Daniels' pleads with the dean to pay off the officials like they usually do but dean's decision stands firm. That leaves Alex to start as QB, who's been complacent being the back-up quarterback, fearing the pressures of having to be the number one guy and just wanting to party. Rather than stepping up in a moment of crisis, Alex channels all his wits into getting Travis reinstated for the big game. He visits Travis's transvestite prostitute to get her to change her alibi and absolve Travis of suspension but she won't budge unless Craig, the star of the team, allows her (or him) to perform fellatio on him. To his surprise, Craig's possessive girlfriend is okay with it but he soon realizes he's the one who can't go through with it, putting Alex back to square one. Meanwhile, Overland U's male cheerleaders have abducted Sammy and the Goats' mascot, a goat named Billy. The Goat's abduction makes headlines but Sammy's disappearance is yet to be noticed. When Sammy accidentally kills the Billy the goat, he brings it to the field on game-day where the heated blame is immediately pinned on Overland U. Sammy plays along with it. Billy's alleged murder fuels Alex who is now ready to play, realizing he's been selfishly looking for solutions that only benefit him and not his team. The Dean refuses to stand by and watch his team loose after the opposition's ruthless mutilation of Billy the Goat and reverses his decision at game time, allowing Travis James to start instead of Alex. Sammy becomes an accidental legend at the school, Alex a selfless team player and Craig remains the unsung hero overcast by Travis James, guilty as charged.

After a streak of bad luck, the team holds a "Lock-In Party" at the Goat House to build team camaraderie at which Alex and Thad divide the rest of the players into two groups and compete in a drug-fueled Team Building Olympics.