When the Time Window is finally repaired, the Turtles enter into it to head home, but instead of finding themselves back in the lair, our heroes find themselves with Viral! She's escaped from inside Serling and has infected the Window so that she can send her most hated enemies on a harrowing, helter-skelter trip through the past, present and future and make them pay for all the pain they've caused her!

The Turtles journey into cyberspace as Cybernauts on a mission to save as much of Master Splinter as they can find. But, they find far more than they bargined for as an old foe is re-born in the digital world...