After Jackson Oz rescues his best friend, Abraham Kenyatta, from a lion attack in Botswana, Abraham's firsthand account of the attack reveals that the lions are no longer afraid of humans and might be killing for sport. Also, Jamie and Mitch run tests on a lion cub in the Los Angeles Zoo and uncover a link to a chemical made by a biotechnology company, and Chloe Tousignant returns to Paris where she must overcome her own trauma and focus on her work as a government intelligence analyst.

Jackson, Abraham, Mitch, Jamie and Chloe are tasked by a top intelligence agent to find the cause of the strange animal behavior around the world. When the team travels to Mississippi to investigate the wolf attack on the prison, Mitch and Abraham break off to catch one of the wolves, and Chloe, Jackson and Jamie discover that death row inmate escapee Evan Lee Hartley might somehow be involved in the attack. Also, the team meets FBI Agent Ben Shafer, who may know more about the prison fire than he's saying.