Billy Berger and Ky Furneaux are dropped in the bayou and must survive 21 days in the Louisiana swamplands. They are washed out of their shelter by storms and have to tackle deadly snakes at every moment while avoiding the abundant hungry alligators.

Two pairs of strangers, dropped on opposite ends of the remote Panamanian rainforest, eventually meet and must work together to conquer the Everest of extreme survival challenges.