Clint Jivoin and Laura Zerra are Naked and Afraid on a Panamanian island for 21 days. Plagued by sand flies and threatened by snakes and crocodiles the pair have to stick together using all their skills and experience to survive in the tropical hell.

Billy Berger and Ky Furneaux are dropped in the bayou and must survive 21 days in the Louisiana swamplands. They are washed out of their shelter by storms and have to tackle deadly snakes at every moment while avoiding the abundant hungry alligators.