In the mountainous rainforest of Honduras, a survivalist with an unusual past is paired with a hard-headed police detective to try and survive 21 days, but predatorial jaguars, swarms of fire ants and a debilitating injury threaten their challenge.

In sun-scorched Brazil, survivalists Wes and Jesse try to complete their 21-day challenge, but a jaguar crossing into their camp puts them on high alert. Starvation forces Jesse to attack a beehive in search of honey and the entire colony retaliates.