While investigating the DNA from a murder scene, Hawkes discovers that the DNA is connected to more than a dozen cases over a three-state area. But does the city really have a serial killer on their hands, or is there another explanation?

When a software company executive bleeds to death on a Manhattan street, the CSIs must delve into the wet and messy world of food "sploshing" parties - where groups of people experience food in an sensual way - to find his killer.