A new case brings Vanina and Manfredi back together. It was the doctor himself who saw two suspicious men throwing a heavy suitcase soaked in blood into the sea, so Vanina will find herself investigating the murder of a girl that took place in a villa. The victim is the lawyer Lorenza Iannino, of whom no other traces can be found. The villa turns out to be owned by the lawyer Elvio Ussaro, a shady prince of the bar, but a macabre discovery will overturn the course of the investigation. Meanwhile, just when Vanina opens her heart to Manfredi, a family commitment brings her face to face with Paolo again and the unresolved issues of their relationship.