At the invitation of her friend, fertility specialist Naomi Bennett, Addison leaves her job in Seattle and heads to Los Angeles to start a new job at Oceanside Wellness Group and to begin a new life. Not expecting Addison's arrival are Naomi's business partners at the co-op wellness center, her ex-husband, internist Sam Bennett, psychiatrist Violet Turner, pediatrician Cooper Freedman and alternative medicine guru Pete Wilder (who is convinced Addison is there because of their recent kiss). On her first day, Addison is presented a case that could make or break her acceptance among the Oceanside staff.

Addison must turn to Pete for help in treating a newlywed couple who can't consummate their marriage (no matter how much they try), while Violet tries to convince her patient to leave his wife, despite her own inability to move on from her ex, while Cooper investigates why his patients -- four sisters -- are all suffering from a mysterious illness.