During a dark moment in his life, Sheldon finds happiness with a new woman. Meanwhile, he becomes increasingly suspicious about his patient Nick's involvement in Sarah's disappearance.

Amelia, now sober for more than a year and on the mend emotionally, goes on a series of disastrous blind dates set up by the other doctors at the practice. After vowing to be alone indefinitely, she teams up with James on a medical procedure, which leads to dinner -- and the dinner leads to something completely unexpected.